NR 603 Week 1 Case Study Discussions Part 1: Initial Patient Assessment and Differential Diagnosis Introduction: In primary care settings, a comprehensive initial patient assessment is crucial for guiding diagnosis and treatment. This process involves gathering detailed information about the patient’s symptoms, medical history, and physical examination findings, which collectively inform the development of a differential diagnosis. A differential diagnosis is essential in narrowing down the possible conditions that could explain the patient’s presentation and helps in determining the most appropriate diagnostic tests and treatments. Patient Presentation: The patient, a 45-year-old female, presents with a chief complaint of persistent fatigue and generalized weakness for the past three months. She reports that the fatigue is worsening, and it is now interfering with her daily activities. The patient describes the fatigue as a constant, dull feeling of tiredness that does not improve with rest. Alongside fatigue, she has experienced intermittent headaches and a 10-pound unintentional weight loss over the past two months. The patient denies any changes in her diet or exercise routine and does not report any recent travel history. Her medical history is significant for hypertension, managed with lisinopril, and hyperlipidemia, treated with atorvastatin. There is no family history of chronic illnesses such as diabetes or cardiovascular disease. The patient is a non-smoker, consumes alcohol occasionally, and works as a school teacher. She reports feeling more stressed than usual at work due to recent curriculum changes but has not experienced any major life changes. Physical Examination Findings: During the physical examination, the patient appears slightly pale but is in no acute distress. Her vital signs are as follows: blood pressure 130/85 mmHg, heart rate 78 beats per minute, respiratory rate 16 breaths per minute, and temperature 98.6°F. The cardiovascular and respiratory exams are unremarkable, with normal heart sounds and clear lung fields bilaterally. The abdominal exam reveals no tenderness, organomegaly, or masses. Neurological examination is within normal limits, with no focal deficits. However, a mild pallor is noted in the conjunctivae, and there is slight tachycardia observed. Differential Diagnosis:

1. Iron Deficiency Anemia: The patient’s fatigue, pallor, and tachycardia suggest the possibility of iron deficiency anemia, especially given the unintentional weight loss and headache. Iron deficiency anemia is a common condition in women, particularly those who may have dietary insufficiencies or chronic blood loss.
2. Chronic Fatigue Syndrome (CFS): Chronic fatigue syndrome could be considered, given the chronicity of the fatigue and its impact on daily functioning. However, CFS is a diagnosis of exclusion, and other causes of fatigue must be ruled out first.
3. Hypothyroidism: Fatigue, weight changes, and cold intolerance can indicate hypothyroidism. The absence of other symptoms like dry skin or constipation makes this less likely, but it remains a differential to consider, especially given the gradual onset of symptoms.
4. Depression: The patient reports increased stress at work, which, combined with the fatigue and weight loss, could suggest a depressive disorder. Depression can manifest with physical symptoms like fatigue and weight changes, and should be considered in the differential diagnosis.
5. Malignancy: Although less likely, the unintentional weight loss and persistent fatigue could be early signs of a malignancy. This possibility warrants further investigation, particularly if the patient has risk factors or other concerning symptoms emerge.

Conclusion: Developing a differential diagnosis is a critical step in managing a patient with nonspecific symptoms like fatigue. By considering a range of potential conditions, the healthcare provider can prioritize diagnostic testing and develop an appropriate management plan. In this case, further tests, including complete blood count (CBC), thyroid function tests, and possibly imaging studies, will be necessary to narrow down the diagnosis and guide treatment. References:

• World Health Organization. (2020). Anemia. https://www.who.int/health-topics/anemia
• National Institutes of Health. (2021). Hypothyroidism. https://www.nih.gov/hypothyroidism
• American Psychiatric Association. (2013). Diagnostic and Statistical Manual of Mental Disorders (5th ed.). Arlington, VA: American Psychiatric Publishing.