Severe symptoms of toxicity can denote lead poisoning based on the amount of lead absorbed. According to Markowitz (2021), modest, high and chronic exposure to leads may result in no immediate symptoms but increase the risks for the long-term development of diverse health outcomes. Published in 2021 Toxicology And Epidemiology Discussion Paper, the article by Markowitz on lead exposure and poisoning prevention and treatment practices among children. Practical strategies to reduce the exposure and toxicity or clinical issues related to lead exposure align with developing and adopting effective measures to reduce or minimize the lead the children are exposed to. Markowitz (2021) identified that exposure to lead poisoning causes sleep-related issues later in life.

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Regarding the selected article, the significance is global as it provides knowledge related to lead poisoning among children and strategies which would be critical in helping in reversing the effects of the poisoning among children. The organ which is most affected by the accumulation of lead poisoning is the brain (Obeng-Gyasi, 2018)). While cases of death may be low among children, fetal levels of exposure among children increase their risk of demise at lower ages. More so, by understanding the diverse sources of lead exposure among children, the article enables the building of successful intervention measures for protecting children from adversities related to lead exposure and poisoning (Mohammadyan et al., 2019)Toxicology And Epidemiology Discussion Paper. Ingestion is recognized as the primary entry route; hence, the article contributes to global agencies’ effective strategies to reduce the issues related to lead poisoning. Finally, practical measures to reduce the exposure include addressing or eliminating environmental exposure, including non-nutritive hand-to-mouth children’s behaviors, promoting adequate nutrition and chelation therapy. The study utilizes a systematic review, drawing from diverse literature, to present the magnitude of the problem and related interventional measures. The article is, in turn, a comprehensive one and precise in stating the focused problem and outcomes. The study results indicate that, while developing and reducing cases of Lead poisoning in the U.S., there are multiple sources of lead exposure to children, such as paints and water in schools; hence millions of children will continue being exposed to the problem. While exposure is a reality, intervention measures should focus on building a successful education problem to make the population aware of the impending problem and related ramifications of this issue later in the children’s lives Toxicology And Epidemiology Discussion Paper. Referencing Markowitz, M. (2021). Lead Poisoning: An Update. Pediatrics in Review42(6), 302–315. https://doi.org/10.1542/pir.2020-0026